An animal model of cutaneous cyst development enables the identification of three QTLs including the homologue of a human locus (TRICY1)

Using inbred BN and LE/Stm rats susceptible and resistant, respectively, to chemically induced cutaneous cyst development we were able to further unveil the genetic architecture of inherited multiple cyst formation. N-methyl-N-nitrosourea-treated (BN x LE) F2 intercross rats proved to develop differential numbers of cutaneous cysts, demonstrating epidermal, trichilemmal and verrucous keratinization types. Male rats developed significantly more cysts per animal than females. QTL interval mapping yielded three loci on rat chromosomes 1, 8 and 11 (Ccd1, Ccd2, Ccd3) linked to cutaneous cyst formation.

Source: Journal of Investigative Dermatology - April 26, 2019 Category: Dermatology Authors: I. Cosgarea, B. Koelsch, C. Fischer, K.G. Griewank, L. van den Berg, A. Kutritz, D. Schadendorf, A. Kindler-R öhrborn Tags: Letters to the Editor Source Type: research