At-a-glance - Pollens, climate and allergies: Quebec initiatives.

This article presents the scientific data underpinning the Strategy and initial successes of the action taken under the Strategy. PMID: 31021065 [PubMed - in process]
Source: Health Promotion and Chronic Disease Prevention in Canada - Category: International Medicine & Public Health Tags: Health Promot Chronic Dis Prev Can Source Type: research

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Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Authors: Canonica GW, Devillier P, Casale T, Demoly P, Bos C, Karagiannis E, Passalacqua G, Wahn U, Mascarell L Abstract Introduction: Allergen bioavailability underpins the efficacy and safety of SLIT tablets. Three product-related factors are likely to influence this: tablet potency, formulation and sublingual holding time. Areas covered: Tablet formulation determines the rate and extent of solubilized allergen release. Using validated in vitro dissolution assays, the two licensed grass pollen SLIT tablets are shown to release ≥85% of their total allergenic activity within several minutes. Sublingual holding t...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
PMID: 31409100 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
ConclusionIL ‐17A potentiated IL‐13‒driven STAT6 activation through the downregulation of SOCS1 expression, leading to enhancement of eotaxin‐3 production by HNECs. These factors contributed to eosinophilic inflammation in AR.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Asthma and rhinitis may share pathogenic mechanisms, and extensive investigation has been devoted to exploring their reciprocal impact. A recent prospective study investigated the prevalence of rhinitis and its phenotypes, symptom severity, and medication use in 619 asthmatic children (1). Rhinitis was found to be a common asthma comorbidity (93.5%) and was refractory to standard rhinitis medications. Perennial allergic rhinitis with seasonal exacerbation due to poly-allergy was common (34.2%), mostly severe, and often associated with difficult-to-control asthma.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
AbstractThis multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14 –55 years and had allergic rhinitis and/or asthma, which was due to house dust mite sensitisation, for at least 2 years. Overall, 296 patients were included; 60% had allergic rhinitis (mostly persistent moderate-to-severe) and 40% had rhinitis and asthma (mostly intermittent or mild-to-persisten t). Patients with rhinitis had moderately reduced quality of life, which was significantly worse in adults than adolescents. The impact of asthma on quality of lif...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Allergic rhinitis is a common disorder that regularly occurs in children and adolescents. The disease is associated with other allergic diseases, such as asthma, and it carries a heavy burden, with effects on sleep, school performance, and quality of life. Classic symptoms include sneezing, rhinorrhea, nasal obstruction, and nasal itching. When the eyes are involved, the term allergic rhinoconjunctivitis is used. Triggers may include airborne pollens, molds, dust mites, and animals. Skin or blood allergy testing can be a useful diagnostic modality that may guide therapy. Immunotherapy can prevent the development of further...
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
In this study we aimed to comparatively evaluate the serum concentrations of dehydroepiandrosterone sulfate (DHEA‐S) and cortisol in patients with allergic rhinitis and healthy control subjects.MethodsMorning fasting blood samples were obtained from 96 participants, including 66 patients with allergic rhinitis (mean age, 28 ± 10.7 years; range, 11‐59 years) and 30 healthy control subjects (mean age, 32.4 ± 11.1 years; range, 14‐57 years). Total immunoglobulin E (IgE), DHEA‐S, and cortisol concentrations were measured by radioimmunoassay.ResultsFemale patients with allergic rhinitis exhibited lower DHE...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: Application of the mapping function enabled the calculation of QALDs associated with the treatment, with the caveat that data were extrapolated from grass seasonal allergy to tree seasonal allergy. The results showed a significant QALD benefit of the treatment over placebo in treatment of tree pollen-induced rhinoconjunctivitis. PMID: 31352853 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
To evaluate the role of atopy (i.e. atopic dermatitis, allergic rhinitis, asthma, and food allergies) and its consequences on developing meatal stenosis in boys.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research
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