Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats

In conclusion, this study demonstrates that a polyphenol extract from mature leaves of Q. ilex improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis, probably through mitogen-activated protein kinase/nuclear transcription factor-kappa B inhibition and Nrf2/heme oxygenase-1 activation signaling pathways, thus reducing the production of Th1 proinflammatory cytokines and cyclooxygenase-2 and inducible nitric oxide synthase overexpression. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Planta Medica - April 23, 2019 Category: Drugs & Pharmacology Authors: Castej ón, Maria Luisa Rosillo, Maria Ángeles Villegas, Isabel S ánchez-Hidalgo, Marina Hadidi, Lila Zaidi, Farid Alarc ón-de-la-Lastra, Catalina Tags: Original Papers Source Type: research