UCLA Depression Grand Challenge seeks votes in competition for $100,000 grant

When “Game of Thrones” star Sophie Turner recently spoke about her years of battling severe depression, it once again shed light on both the prevalence and stigma of a problem that affects more than 300 million people worldwide.A UCLA-led project aiming to address that stigma is competing for $100,000 in funding from the  Goldhirsh Foundation, a Los Angeles nonprofit. The foundation’sMy LA 2050 Grants Challenge will distribute a total of $1 million to 10 organizations that are working to make Los Angeles the best place to play, connect, live, create and learn by 2050.UCLA ’s project, “Humanizing and Destigmatizing Depression,” is a part of the UCLA Depression Grand Challenge, a campuswide effort UCLA launched in 2015 to reduce the burden of depression worldwide. The grand challenge involves more than 100 researchers from 25 academic departments who are developing better understanding of depression and improved methods for prevention and treatment. One of its key goals is to develop targeted strategies to defeat the stigma associated with depression by raising awareness and fostering hope.The initiative competing for the LA 2050 grant would feature six regional events in Los Angeles designed “to spark conversation and empower Los Angeles to humanize depression.” Those discussions would in turn fuel digital media campaigns that would be disseminated throughout and beyond Los Angeles.“We aim to inspire mem...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
This report therefore uses quality assurance data looking into whether sensory processing sensitivity (SPS) affects treatment outcome among patients with OCD. SPS is a personality trait regarding heightened levels of emotional reactivity and deeper cognitive processing of emotional stimuli. Patients received concentrated exposure treatment for obsessive-compulsive disorder (OCD). They were assessed with one of the most widely used questionnaires for measuring SPS, the Highly Sensitive Person Scale (HSPS). Analyses tested whether HSPS scores at pre-treatment affected treatment outcome, and if sensitivity changed from pre-to...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
In this study, antidepressive efficacy of white ginseng (Panax gingseng Meyer, WG) was evaluated in stressed ovariectomized rats. Female Sprague Dawley rats were ovariectomized and repeatedly restraint stressed for 2 weeks (2h/day). Thirty minutes before restraint stress, rats were administered saline (control), WG 200 mg/kg (p.o.), WG 400 mg/kg (p.o.), or fluoxetine (PC, 10 mg/kg, i.p.). Tail suspension test (TST) and forced swimming test (FST) were performed to assess antidepressant effect of WG. After behavioral tests, levels of serum corticosterone (CORT) and hippocampal 5-HT were measured. Significant decrease of immo...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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Publication date: Available online 15 October 2019Source: Molecular and Cellular ProbesAuthor(s): Danning Lou, Jun Wang, Xiaohang WangAbstractMajor depressive disorder (MDD) is one of the most prevalent psychiatric disorders worldwide and a major public health concern that is associated with grave consequences. Systemic complexity and feedback processes among diverse drivers of the depression disorder contribute to the considerable variation in responses to the treatment of depression. Dysfunctional microRNA (miRNA) is involved in MDD. miR-124 is enriched in the brain and may be critical in neuronal differentiation. Previo...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Objectives: To evaluate whether fall risk in older adults is associated with the use of selective serotonin receptor inhibitor (SSRI) monotherapy among geriatric outpatients, and whether this association is moderated by the presence of depressive di...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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