019 Serum RIP3 level as a severity-predictive marker for Stevens-Johnson syndrome and toxic epidermal necrolysis

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases. It is often difficult to distinguish SJS/TEN and other types of generalized skin eruptions, such as maculopapular exanthema (MPE) and erythema multiforme (EM) at the early stage. Although keratinocytes have been suggested to die as apoptosis in SJS/TEN, our recent study revealed that necroptosis, programmed necrosis, also contribute to keratinocyte death in SJS/TEN. Necroptosis is mediated by receptor-interacting kinase-3 (RIP3) and mixed lineage kinase domain-like pseudokinase phosphorylation.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: A. Hasegawa, S. Shinkuma, R. Hayashi, N. Hama, H. Watanabe, M. Kinoshita, Y. Ogawa, R. Abe Tags: Adaptive and Auto-Immunity Source Type: research