057 Interleukin-6 regulates psoriasis-like dermatitis induced by blockade of programmed cell death 1 signaling

We recently reported that serum levels of interleukin (IL)-6 were increased in melanoma patients who developed neutrophil-rich psoriasiform dermatitis during immunotherapies with anti-programmed cell death 1 (PD-1) antibodies. To identify the roles of IL-6 in its pathogenesis, a murine model of imiquimod (IMQ)-induced psoriasiform dermatitis was used, by which we analyzed the difference between PD-1 deficient (PD-1-/-) mice and wild-type (WT) mice. PD-1-/- mice presented significantly more severe psoriasiform dermatitis with thicker ear swelling and higher PASI score, representing the severities of erythema, scaling and skin thickness, than WT mice (5.6 ± 0.24 v.s.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research