059 Trans-disease meta-analysis between psoriasis and type 2 diabetes reveals shared genetic signals

Psoriatic patients are at increased risk for metabolic disorders, imposing additional burdens on healthcare resources. Although clinically distinct, type 2 diabetes (T2D) and psoriasis are significantly associated (with published studies yielding ORs ≈1.5). Since the incidence of T2D is rapidly increasing in the USA, it is crucial to understand how its biological mechanisms relate to psoriasis. To investigate the genetic similarities and differences between psoriasis and T2D, we conducted a large-scale trans-disease meta-analysis incorporating results from previous association studies for psoriasis (11,024 cases, 16,336 controls) and T2D adjusted for BMI (74,124 cases, 824,006 controls), utilizing 8,016,731 well-imputed markers from both diseases.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: M.T. Patrick, P.E. Stuart, X. Yin, Z. He, J. Gudjonsson, J. Voorhees, R.P. Nair, D. Liu, J.T. Elder, L. Tsoi Tags: Adaptive and Auto-Immunity Source Type: research