064 Mucosal-associated invariant T (MAIT) cell-derived IL-17A and IL-17F production is IL-23-independent and biased towards IL-17F

The requirement for IL-23 in IL-17A and IL-17F production in humans is incompletely understood. Preclinical data support IL-17F, together with IL-17A, as a key driver of chronic tissue inflammation.1 Dysregulation in the frequency and function of MAIT cells, an innate-like T cell population, has been associated with IL-17A-mediated inflammatory diseases, including psoriasis and psoriatic arthritis.2,3 However, IL-17F production by MAIT cells remains largely unexplored. Optimal MAIT cell IL-17A and IL-17F production occurred upon T cell receptor triggering with IL-12 and IL-18, independently of IL-23, as shown by MR1-presented riboflavin metabolites from E.coli or polyclonal anti-CD3/CD28 activation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research