065 Microneedle arrays engineer the skin microenvironment to promote allergen tolerance

Allergic contact dermatitis (ACD) is a T-cell-mediated immune response to repeated contact with allergens (e.g. nickel or poison ivy). Current treatments involve topical corticosteroids, which non-specifically and transiently suppress inflammation without addressing the underlying immune dysfunction. Here we present a novel approach to induce systemic allergen-specific tolerance by delivering both allergen and a tolerance-favoring immune modifier into the same cutaneous microenvironment. Dissolvable microneedle arrays (MNAs) simultaneously deliver hapten or protein allergens with vitamin D3 analog MC903 to induce a tolerogenic skin microenvironment.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research