169 Single-cell profiling of cutaneous T-cell lymphoma reveals underlying heterogeneity predicting disease progression

S ézary syndrome (SS) is an aggressive form of cutaneous T cell lymphoma (CTCL) characterized by involvement of both the skin and the blood. The guarded prognosis for SS reflects a lack of reliably effective therapies. SS patients undergoing treatment often experience transient responses and relapses , supporting the hypothesis that relevant biological heterogeneity exists within the malignant cell population of individual patients. Using single-cell RNA sequencing and machine-learning approaches, we defined a model featuring distinct transcriptomic states within SS.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: N. Borcherding, A. Voigt, V. Liu, B. Link, W. Zhang, A. Jabbari Tags: Carcinogenesis and Cancer Genetics Source Type: research