373 Comparative analysis of acne and rosacea transcriptomes identifies compounds that target distinct disease-specific signatures of pathogenic inflammation and lipid biosynthesis

Acne and rosacea are both prevalent inflammatory conditions with negative psychosocial impact and unmet clinical needs. Knowledge of distinct gene expression changes and implicated biologic pathways specific to acne versus rosacea is needed to streamline the selection of candidate compounds for rapid testing and development in the appropriate patient populations. We pooled and compared transcriptomes from N=12 acne patients, N=19 rosacea patients, and N=22 respective controls to obtain differentially expressed genes, then performed Ingenuity upstream regulator analysis to identify compounds highly predicted to target aberrantly regulated genes within each disease.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research