492 Identification of skin-resident Treg cells in allergen-specific immunotherapy mouse model

CD4+ Foxp3+ regulatory T (Treg) cells represent a subset of CD4+ T cells that function to suppress immune responses mediated by autoreactive or pathogenic effector T (Teff) cells, thus establishing and maintaining tissue immune homeostasis. An imbalance between pathogenic Teff cells and Treg cells results in chronic allergic inflammation, such as asthma and atopic dermatitis (AD). Allergen-specific immunotherapy (ASIT) has been reported to be an effective way to treat AD. Our previous work established a murine model of ASIT and demonstrated clinical and histological improvement, with successful induction of skin Treg cells that produced high levels of IL-10.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research