670 Topical treatment for abnormal scars using spherical nucleic acids

Abnormal scarring, manifesting as hypertrophic or keloid scars, affects millions of people every year after surgeries, injury, and even as residual from skin disease. These overgrown scars can be painful, itchy, and often disfiguring. Although many treatments for abnormal scars exist, they are often invasive and do not prevent scar recurrence. Spherical nucleic acids (SNAs) are nanoparticle-oligonucleotide conjugates consisting of a nanoparticle core and dense shell of oriented oligonucleotides.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: A. Ponedal, S. Zhu, A.J. Sprangers, X. Wang, D.C. Yeo, D.C. Lio, M. Zheng, S.P. Narayan, M. Capek, A.S. Paller, C. Xu, C.A. Mirkin Tags: Pharmacology and Drug Development Source Type: research