821 Anti-tumor activity induced by topical delivery of HSP70iQ435A

Inducible HSP70 (HSP70i) is implicated in the development of autoimmune vitiligo and is overexpressed in melanoma. We generated an expression construct encoding a single amino acid modification to the dendritic cell (DC) activating moiety (HSP70iQ435A). A topical application of the DNA construct has now demonstrated efficacy in reversing autoimmunity in Sinclair swine without obstructing anti-melanoma responses. We postulate that treatment with the HSP70iQ435A construct elicits a humoral response to stress protein selectively expressed on the surface of melanoma cells, providing measurable anti-tumor protection.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: D. Jaishankar, C. Cosgrove, E. Dellacecca, S. Henning, J. Mahon, I.C. Le Poole Tags: Pigmentation and Melanoma Source Type: research