Nigeria: Researchers Move to Unveil Complete Protection Against Malaria

[Guardian] Ahead of the World Malaria Day (WMD) holding next Thursday, researchers are to begin the first large field trial in West Africa of a malaria vaccine that offers complete protection against the disease.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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ConclusionAccording to our results, Nested PCR method had higher sensitivity than LM and is suggested as a good approach for malaria detection. Consideration the wide diversity of tested isolates and the importance of vaccine development, which is affected by this diversity, further studies are needed in this regard.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ACS Chemical BiologyDOI: 10.1021/acschembio.9b00739
Source: ACS Chemical Biology - Category: Chemistry Authors: Source Type: research
Malaria parasites undergo several stages in their complex lifecycle. To achieve reductions in both the individual disease burden and malaria transmission within communities, a multi-stage malaria vaccine with high effectiveness and durability is a more efficacious strategy compared with a single-stage vaccine. Here, we generated viral-vectored vaccines based on human adenovirus type 5 (AdHu5) and adeno-associated virus serotype 1 (AAV1) expressing a fusion protein of the pre-erythrocytic stage Plasmodium falciparum circumsporozoite protein (PfCSP) and the transmission-blocking sexual stage P25 protein (Pfs25). A two-dose h...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Funding Opportunity RFA-AI-19-059 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to stimulate basic research, discovery, and early translational research to enable and accelerate the generation of highly efficacious pre-erythrocytic stage, sporozoite-based vaccines. Cross-fertilization and collaboration among investigators from malaria vaccine research and other basic research areas such as parasite biology, parasite genomics, pathogenesis, and host immunology are highly encouraged. The goal is to generate one or more promising vaccine candidates against human malaria that exhibit performan...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Abstract As phagocytosis is the first line of defense against malaria, we developed a phagocytosis assay with Plasmodium vivax (P. vivax) merozoites that can be applied to evaluate vaccine candidates. Briefly, after leukocyte removal with loosely packed cellulose powder in a syringe, P. vivax trophozoites matured to the merozoite-rich schizont stages in the presence of the E64 protease inhibitor. The Percoll gradient-enriched schizonts were chemically disrupted to release merozoites that were submitted to merozoite opsonin-dependent phagocytosis in two phagocytic lines with human and mouse antibodies against the N...
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Bill Gates told an audience at the University of Cambridge on Monday that global malnutrition will be solved and malaria will be virtually eliminated by 2040 if world leaders choose to fund scientific innovation. Speaking at the Cambridge Union in England, the Microsoft co-founder said: “I’m lucky that my work gives me a view of all the amazing discoveries in the works right now. That’s why I’m able to predict the future.” Gates was named the 2019 recipient of the Professor Hawking Fellowship, founded by the Cambridge Union Society in 2017 in honor of Stephen Hawking’s contribution to t...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized global health Source Type: news
Plasmodium vivax malaria incidence has increased in Latin America and Asia and is responsible for nearly 74.1% of malaria cases in Latin America. Immune responses to P. vivax are less well characterized than those to P. falciparum, partly because P. vivax is more difficult to cultivate in the laboratory. While antibodies are known to play an important role in P. vivax disease control, few studies have evaluated responses to P. vivax sexual stage antigens. We collected sera or plasma samples from P. vivax-infected subjects from Brazil (n = 70) and Cambodia (n = 79) to assess antibody responses to domain 1 of the gametocyte/...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
30 million to be offered free NHS flu jab this winter Related items fromOnMedica Swine flu jab in pregnancy safe for children as well as mothers Routine child vaccination coverage rates fall World ’s first malaria vaccine piloted in Malawi babies Parental confidence in immunisation programme ‘very high’ Easter travellers warned over Europe measles outbreak
Source: OnMedica Latest News - Category: UK Health Source Type: news
[WHO] September 13, will forever be a memorable day for Noreen Koech, 22.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[Malawi News Agency] Lilongwe -Fainesi Maida (not real name) of Bereu Village in Traditional Authority (TA) Maseya's area in Chikhwawa District never saw two of her three babies grow through to 11 months.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
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