MiR-148-3p inhibits growth of glioblastoma targeting DNA methyltransferase-1 (DNMT1).

In conclusion, miR-148-3p directly repressed the expression of DNMT1, and inhibited proliferation, migration and invasion by regulating DNMT1-RUNX3 axis and the epithelial-mesenchymal transition in GBM. Our findings provide a new foundation for treatment of patients with GBM. PMID: 30982493 [PubMed - as supplied by publisher]
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research