The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man

ConclusionWe report that this cytokine shows no activity in human cells. IL-39 chimera protein failed to induce either IL-6, IL-8, TNF, or IL-17A from leukocytes or STAT3 phosphorylation and thus, remains a ‘theoretical cytokine' in humans.

Source: Inflammation Research - April 12, 2019 Category: Research Source Type: research