Coumarinocoumarin-based fluorescent probe for the sensitive and selective detection of hydrazine in living cells and zebra fish

Publication date: Available online 13 April 2019Source: Chinese Chemical LettersAuthor(s): Qian Fang, Lei Yang, Haiqing Xiong, Shaohui Han, Yun Zhang, Jingpei Wang, Wenqiang Chen, Xiangzhi SongAbstractA coumarinocoumarin-based fluorescent probe, JCCA, was developed for the detection of N2H4. JCCA exhibited a fast turn-on fluorescence enhancement in response to N2H4 with good selectivity, sensitivity and a detection limit of 7.4 nmol/L. Significantly, JCCA displayed a good capability for visualizing N2H4 in living cells and zebra fish.Graphical abstractA new fluorescent probe was developed for the detection of hydrazine (N2H4) with high sensitivity, good selectivity, a fast response time (3 min) and a low detection limit (7.4 nmol/L). And this probe was successfully applied to detect N2H4 in living cells and zebra fish with low cytotoxicity.

Source: Chinese Chemical Letters - April 13, 2019 Category: Chemistry Source Type: research