Intratumoral 18 F-FLT infusion in metabolic targeted radiotherapy

ConclusionConsidering the biochemical stability of18F-FLT and the physical properties of localized18F, this study shows that TRT via intratumoral infusion of18F-FLT and 5FU could provide a new effective treatment option for solid tumors. Using this approach in a colorectal tumor model, the tumor and its metastases could be efficiently irradiated locally with much lower doses absorbed by healthy tissues than withi.t. administration of18F-FDG or conventional EBRT.
Source: EJNMMI Research - Category: Radiology Source Type: research