Catheter-related bloodstream infections: a root cause analysis in a series of simultaneous Ochrobactrum anthropi infections.

Catheter-related bloodstream infections: a root cause analysis in a series of simultaneous Ochrobactrum anthropi infections. Curr Pharm Biotechnol. 2019 Apr 05;: Authors: Caroleo B, Malandrino P, Liberto A, Condorelli D, Patanè F, Maiese A, Casella F, Geraci D, Ricci P, Di Mizio G Abstract Catheter-related bloodstream infections (CRBSIs) pathogenesis is complex and multifactorial mostly due to cutaneous microorganisms migration through the catheter insertion site and catheter tip colonization. Ochrobactrum anthropi is a gram-negative bacteria belonging to the Brucellaceae and related infections are especially observed in immunocompromised patients. Therefore, O. anthropi infection prevention and surveillance is a relevant issue for healthcare system and risk management, in order to improve healthcare quality and patient safety. Four cases of anthropi-related CRBSIs occurred in immunodepressed patients under chemotherapy treatment are reported and the possible prevention and surveillance strategies are analyzed. In the reported cases, all infections occurred almost simultaneously in Oncology Unit, leading to hypothesize an identical infection source. Subsequently, a clinical audit was performed in order to investigate infection origin and implement prevention and control strategies. Clinical audit allowed to identify the hand hygiene defects as the primary source of the infections, responsible for the catheter flushing solution contamination. The a...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research

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