Association Between Severe Periodontitis and Obesity Degree: A Preliminary Study

Conclusions: In the present study, severe periodontitis was associated with obesity but not with overweight. Patients diagnosed with obesity should be referred for periodontal evaluation.
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research

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Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit overt metabolic phenotypes when given ad libitum food access. These results, and findings of ghrelin resistance in obese states, imply nutritional state dependence of ghrelin’s metabolic actions. Here, we hypothesized that liver-enriched antimicrobial peptide-2 (LEAP2), a recently characterized endogenous GHSR antagonist, blunts ghrelin action during obese states and pos...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Ghrelin is a key signal driving energy seeking and storage in order to reverse energy deficit. In line with this view, the metabolic status of an organism predicts sensitivity to ghrelin, with fasting increasing and obesity decreasing ghrelin sensitivity, respectively. However, the mechanism responsible for controlling this sensitivity is unknown. In this issue of the JCI, Mani and colleagues show that plasma levels of plasma liver-enriched antimicrobial peptide-2 (LEAP2), a recently identified hormone that antagonizes the ghrelin receptor, are inversely correlated with those of plasma acyl-ghrelin under conditions of both...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for produci...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
There is emerging evidence of a relationship between short sleep duration and poor quality of sleep with overweight and obesity. This has been clearly demonstrated in adults and there is increasing evidence of this relationship in children and adolescents. One area that needs more study is whether sleep patterns early in life are important for the development of subsequent obesity. This may be complicated because sleep in infants is more fragmented because it is interspersed with feedings. In this volume of The Journal, Tuohino et al report the results of their study that evaluated whether shorter sleep duration at 3 and 8...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
ABSTRACT Aniridia is a congenital eye disorder with a variable degree of hypoplasia or absence of iris tissue. It is caused by loss of function of the PAX6 gene and may be an isolated ocular abnormality or part of a syndrome. WAGRO refers to a rare genetic condition leading to Wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity and is caused by a deletion of the short arm of chromosome 11 (11p), where the PAX6 gene is located. Here, we report on an 8-year-old boy with aniridia, polar cataract, and lens subluxation along with neuropsychomotor and speech delays. Karyotype evaluation showed an inte...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
Increasing numbers of middle-aged Americans appear to be developing cancers that can be associated with obesity, new data suggest.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Conditions:   Type2 Diabetes;   Obesity;   Metabolic Syndrome Interventions:   Other: cooling using a water-perfused vest;   Other: thermoneutrality Sponsors:   University of Aarhus;   Aarhus University Hospital;   Steno Diabetes Center Copenhagen Recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Non-alcoholic Steatohepatitis (NASH) Interventions:   Procedure: Endoscopic Sleeve Gastroplasty (ESG) with OverStitch® system + Lifestyle modifications;   Procedure: Laparoscopic Sleeve Gastrectomy (LSG) + Lifestyle modifications Sponsor:   Instituto de Investigación Marqués de Valdecilla Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Overweight;   Obesity;   Body Weight Interventions:   Other: Low fat meal;   Other: Moderate fat meal;   Other: High fat meal;   Other: High fat liquid meal Sponsor:   USDA, Western Human Nutrition Research Center Recruiting
Source: - Category: Research Source Type: clinical trials
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