Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield

Among women, there is significant variability in the age at menopause, the rate of decline in oocyte number, and the ability to reproduce. Various methods have been developed to assess ovarian response; however, limitations exist in their clinical utility. Among these, anti-m üllerian hormone (AMH) and antral follicle count (AFC) have been described as the most predictive (1,2). Models that incorporate both of these measurements can even further enhance predictive value by including chronological age (3).

Source: Fertility and Sterility - March 31, 2019 Category: Reproduction Medicine Authors: Brent Monseur, Gaya Murugappan, Jason Bentley, Nelson Teng, Lynn Westphal Tags: Oral Presentation Source Type: research