Atrial electrical remodeling induced by chronic ischemia and inflammation in patients with stable coronary artery disease.

Atrial electrical remodeling induced by chronic ischemia and inflammation in patients with stable coronary artery disease. Chin J Physiol. 2019 Jan-Feb;62(1):11-16 Authors: Serban RC, Balan AI, Perian M, Pintilie I, Somkereki C, Huţanu A, Scridon A Abstract The pathophysiology of coronary artery disease (CAD) includes low-grade chronic inflammation. At its turn, inflammation is known to promote myocardial structural remodeling and to increase vulnerability to atrial arrhythmias. Meanwhile, the impact of chronic inflammation on the electrophysiological properties of the atria remains unknown. We aimed to evaluate the impact of low-grade chronic inflammation on atrial electrophysiology in patients with stable CAD undergoing elective coronary artery bypass grafting (CABG). Circulating levels of several inflammatory, angiogenesis, and endothelial dysfunction markers were determined 1 day before CABG in 30 consecutive CAD patients. Right atrial appendage samples were collected during the CABG procedure; action potential recordings were performed in six study patients using the microelectrode technique. Interleukin (IL)-1b (r = 1.00, P = 0.01), IL-6 (r = 0.98, P < 0.01), vascular endothelial growth factor (VEGF) (r = 0.98, P < 0.01), and hemoglobin (r = 0.98, P < 0.01) levels significantly positively correlated with the duration of atrial depolarization. Consequently, IL-6, VEGF, and hemoglobin (r = -0.86, P = 0.03 for all) level...
Source: The Chinese Journal of Physiology - Category: Physiology Tags: Chin J Physiol Source Type: research