Genetic markers for the diagnosis and prognosis of pheochromocytoma.

Genetic markers for the diagnosis and prognosis of pheochromocytoma. Expert Rev Endocrinol Metab. 2009 Jan;4(1):45-52 Authors: Thouënnon E, Pierre A, Guillemot J, Yon L, Eisenhofer G, Anouar Y Abstract The last 5 years have witnessed important advances in understanding the mechanisms of tumorigenesis of chromaffin cells. Large-scale microarray analyses of pheochromocytomas have identified two distinct gene-expression profiles encompassing all hereditary and sporadic tumors. Gene-expression profiling of benign and malignant pheochromocytomas is providing a better understanding of the mechanisms of metastasis. Such studies hold promise for the development of new prognostic markers for early detection of malignant pheochromocytoma and for the identification of novel targets for therapeutic intervention. PMID: 30934373 [PubMed]
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research