The missing link between familial Mediterranean fever and recurrent aseptic meningitis

Yusef et  al. reported a case of familial Mediterranean fever (FMF) presenting with recurrent aseptic meningitis (RAM).1 There is no consensus on a possible association between the two conditions, and we have proposed criteria to assess the strength of evidence of case reports.2 In the present case, FMF was diagnosed based on a homozygous E148Q mutation on the MEFV gene. However, the pathogenicity of the E148Q mutation is uncertain, and the diagnosis of FMF requires clinical features that are missing in this case.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Letter to the Editor Source Type: research

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AbstractBacterial meningitis is a serious life threatening infection of the CNS. To cause meningitis, blood –borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that comprise the blood–brain barrier. BECs help maintain brain homeostasis and they possess an array of efflux transporters, such asP-glycoprotein (P-gp), that function to efflux potentially harmful compounds from the CNS back into the circulation. Oftentimes, efflux also serves to limit the brain uptake of therapeutic drugs, representing a major hurdle for CNS drug delivery. During meningitis, BEC barrier integrity is com...
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research
ConclusionLiposomal cytarabine permits prolonged CSF drug exposure, with cytotoxic cytarabine concentrations that are detectable for 4  weeks in the majority of patients. The preserved clinical activity seen in patients with inferior CSF drug concentrations (
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
[Shabait] Sawa -Seminar on the control and prevention of communicable diseases in general and that of meningitis vaccination program that is set to be conducted on the coming months of November and December was organized to the staff members of the Sawa National Military Training Center.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
In this study we inoculated ground chicken meat with 25 individual isolates of clinical uropathogenic E. coli (UPEC) and newborn meningitis causing E. coli (NMEC), isolates from retail chicken meat (CM), as well as retail chicken-skin isolates identified in our laboratory (CS). We then determined their gamma radiation inactivation kinetics (D10-value). The mean D10-value for all isolates (n = 25) was 0.30 kGy. The mean D10-value for the UPEC, NMEC, CM, and CS isolates were 0.25, 0.29, 0.29, and 0.39 kGy, respectively. The mean D10-value for the clinical isolates was 0.27 kGy vs. 0.34 kGy for the non-clinical is...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
In recent years nontyphoidal Salmonella has emerged as one of the pathogens most frequently isolated from the bloodstream in humans. Only a small group of Salmonella serovars cause this systemic infection, known as invasive nontyphoidal salmonellosis. Here, we present a focused minireview on Salmonella enterica serovar Panama, a serovar responsible for invasive salmonellosis worldwide. S. Panama has been linked with infection of extraintestinal sites in humans, causing septicemia, meningitis, and osteomyelitis. The clinical picture is often complicated by antimicrobial resistance and has been associated with a large repert...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Minireviews Source Type: research
Group B Streptococcus (GBS) is a major opportunistic pathogen in certain adult populations, including pregnant women, and remains a leading etiologic agent of newborn disease. During pregnancy, GBS asymptomatically colonizes the vaginal tract of 20-30% of healthy women, but can be transmitted to the neonate in utero or during birth resulting in neonatal pneumonia, sepsis, meningitis, and subsequently 10-15% mortality regardless of antibiotic treatment. While various GBS virulence factors have been implicated in vaginal colonization and invasive disease, the regulation of many of these factors remains unclear. Recently, CRI...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Streptococcus pneumoniae is a Gram-positive bacterium belonging to the oral streptococcus species, mitis group. This pathogen is a leading cause of community-acquired pneumonia, which often evades host immunity and causes systemic diseases, such as sepsis and meningitis. Previously, we reported that PfbA is a β-helical cell surface protein contributing to pneumococcal adhesion to and invasion of human epithelial cells in addition to its survival in blood. In the present study, we investigated the role of PfbA in pneumococcal pathogenesis. Phylogenetic analysis indicated that the pfbA gene is highly conserved in S. pne...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conditions:   Serogroup C Meningococcal Meningitis;   Diphtheria Intervention:   Procedure: venepuncture Sponsor:   University of Oxford Not yet recruiting
Source: - Category: Research Source Type: clinical trials
In Reply We thank Burstein and Papenburg, Verd and Moll, and Bonadio for the letters pertaining to our study in which we derived and validated a prediction rule for identifying febrile infants 60 days and younger with serious bacterial infections (SBI). Burstein and Papenburg question the use of the less widely available procalcitonin (PCT) rather than the C-reactive protein. They also suggest considering results of viral multiplex testing in the prediction rule. We chose PCT because of its superiority as a screening biomarker compared with C-reactive protein for invasive bacterial infections (bacteremia and/or bacterial m...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
AbstractThe surgical approach for hypophysectomy has undergone sweeping revolution in the past three decades. With the advent of endoscopes, better instrumentation, better illumination and viewing cameras, endoscopic endo-nasal trans-sphenoidal approach to sella has now largely become the norm. The aim of this study is to present our experience, analysing the surgical outcomes of this approach in patients with pituitary adenoma, pertaining to entirety of tumor removal, alleviation of symptoms and rate of complications. This prospective   study was conducted at our tertiary health care  centre from June 2012 ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
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