In reply —Low-Sodium Intake: A Risk Factor for Stroke?

We are grateful to Drs Musso and Dotto1 for the appraisal of our article on low urinary sodium excretion (UNaV) as an indicator of low sodium intake and increased risk of stroke.2 We agree that the mentioned earlier study by O ’Donnell and colleagues,3 although representative of various populations by including more than 100,000 participants from 17 countries, has some limitations. In particular, the assessment of sodium intake via a single spot urine sample is a major limitation. Actual measurement of 24-hour UNaV in m ultiple urine collections (to account for day-to-day variability), as we did in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, has been shown to be a more accurate method for the assessment of usual sodium intake.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Letter to the Editor Source Type: research