Magnetic System Aims to Make Bariatric Surgery Less Invasive

A recent study concluded that a "first-of-its-kind" magnetic surgical system allows a safe, reproducible, incision-less technique for port-less intraabdominal mobilization. The Magnetic Surgical System, developed by Levita Magnetics, is so unlike current technologies that FDA had to create a whole new category for it when approving it for use, according to Alberto Rodriguez-Navarro, MD, CEO and founder of Levita Magnetics, in an interview with MD+DI. The system consists of an external magnet placed on the skin that controls a shaftless detachable grasper. It enables surgeons to move instruments without the constraints of a fixed-position pivot point, while facilitating access and visualization of the surgical site. In conventional laparoscopic procedures, shafted surgical instruments are introduced by fixed-position trocars inserted through incisions in the abdomen. Because they have a fixed pivot point, using these instruments can affect the surgeon’s vision by cluttering the operative field—they can also cause instrument collisions and restrict movement. Further, the use of trocars is also associated with risks relating to major bowel and vessel injury, incisional pain, bleeding, scarring, hernias, and infection. With magnetic surgery, there are no limitations in moving the instruments. “That’s the beauty of magnetic surgery—that you are not restricted by the entr...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news

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This study was designed to evaluate the clinical and radiographic outcomes of patients with nutcracker syndrome (NCS) who were treated with three-dimensional printing (3DP) extravascular titanium stents (EVTSs). The 3DP EVTS was expected to release the hypertension of the left renal vein (LRV) produced by its compression between the superior mesenteric artery (SMA) and the aorta without causing any complications. METHOD: The pre-operative kidney model of each patient was printed out to enable surgical planning. After that, the EVTS was designed based on the LRV's primitive physiologic structure using computer-aided de...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Publication date: Available online 18 June 2019Source: Neuroscience LettersAuthor(s): Fabiano V. Costa, Julia Canzian, Flavia V. Stefanello, Allan V. Kalueff, Denis B. RosembergAbstractThe ability to detect noxious stimuli is essential to survival. However, pathological pain is maladaptive and severely debilitating. Endogenous and exogenous opioids modulate pain responses via opioid receptors, reducing pain sensibility. Due to the high genetic and physiological similarities to rodents and humans, the zebrafish is a valuable tool to assess pain responses and the underlying mechanisms involved in nociception. Although morphi...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 18 June 2019Source: NeuroscienceAuthor(s): Kimberly Gómez, Alejandro Sandoval, Paulino Barragán-Iglesias, Vinicio Granados-Soto, Rodolfo Delgado-Lezama, Ricardo Felix, Ricardo González-RamírezAbstractHigh voltage-activated (HVA) Ca2+ (CaV) channels are oligomeric complexes formed by an ion-conducting main subunit (Cavα1) and at least two auxiliary subunits (Cavβ and CaVα2δ). It has been reported that the expression of CaVα2δ1 increases in the dorsal root ganglia (DRGs) of animals with mechanical allodynia, and that the transcr...
Source: Neuroscience - Category: Neuroscience Source Type: research
In this study, we determined whether spinal SGK1 signaling contributes to the development of morphine analgesic tolerance. Chronic morphine administration markedly induced phosphorylation of SGK1 in the spinal dorsal horn neurons. Intrathecal injection of SGK1 inhibitor GSK-650394 reduced the development of morphine tolerance with a significant leftward shift in morphine dose-effect curve. Furthermore, spinal inhibition of SGK1 suppressed morphine-induced phosphorylation of nuclear factor kappa B (NF-κB) p65 and upregulation of NMDAR NR1 and NR2B expression in the spinal dorsal horn. In contrast, intrathecal administ...
Source: Neuroscience - Category: Neuroscience Source Type: research
We describe a case of a 70-year old man with sensorimotor chronic inflammatory demyelinating polyneuropathy (CIDP) with small-fibre involvement resulting in severe diffuse neuropathic pain which was refractory to immunotherapy and anti-neuropathic medication. His pain was successfully treated with implantation of a spinal cord stimulation (SCS) system comprising bilateral cervical and lumbar epidural leads. Following SCS programming, he experienced a 50% reduction in average pain severity with substantial improvement in quality of life, persisting at 18 months after surgery. SCS has been employed to treat a variety of ne...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractNeural injury, inflammation, or diseases commonly and adversely affect micturition reflex function that is organized by neural circuits in the CNS and PNS. One neuropeptide receptor system, pituitary adenylate cyclase-activating polypeptide (PACAP;Adcyap1), and its cognate receptor, PAC1 (Adcyap1r1), have tissue-specific distributions in the lower urinary tract. PACAP and associated receptors are expressed in the LUT and exhibit changes in expression, distribution, and function in preclinical animal models of bladder pain syndrome (BPS)/interstitial cystitis (IC), a chronic, visceral pain syndrome characterized by ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 17 June 2019Source: Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical SciencesAuthor(s): David TeiraAbstractIn this paper, I suggest that placebo effects, as we know them today, should be understood as experimental phenomena, low-level regularities whose causal structure is grasped through particular experimental designs with little theoretical guidance. Focusing on placebo interventions with needles for pain reduction -one of the few placebo regularities that seems to arise in meta-analytical studies- I discuss the extent ...
Publication date: Available online 17 June 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Guohua Song, Chuanlong Zong, Mingzhu Shao, Yang Yu, Qian Liu, Hui Wang, Tingting Qiu, Peng Jiao, Zheng Guo, Phoebe Lee, Yi Luo, Xian-Cheng Jiang, Shucun QinAbstractIncreased phospholipid transfer protein (PLTP) activity has been found to be associated with obesity, and metabolic syndrome in humans. However, whether or not PLTP has a direct effect on insulin sensitivity and obesity is largely unknown. Here we analyzed the effect by using PLTP knockout (PLTP−/−) mouse model. ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
We describe a 63-year-old woman with signs and symptoms of intracranial hypertension. Brain MRI revealed hydrocephalus. Venous Doppler ultrasound showed external compression of the omohyoid muscles on the internal jugular veins. During jugular vein decompression, intracranial pressure dropped from 18 to 6  mmHg. Patient is asymptomatic at 2-year follow-up, with decreased brain ventricles. These findings could represent a novel form of high-pressure hydrocephalus that can be successfully treated without a CSF shunt. We called this syndrome JEDI (jugular entrapment dilated ventricles intracranial hype rtension).
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Conclusion A recurrent perineal hernia can be prevented by a solid fixation of the mesh using the technique of a glued mesh repair. This technique shows to be easy, fast and without recurrence. PMID: 31204903 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
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