Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity
Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are “innocent bystanders” unrelated to the problem at hand. Although removing an endometrial polyp may be seen as a relatively benign and safe intervention, myomectomy, and in particular adenomyomectomy, can be substantive surgical procedures, associated with their own potential for disrupting ferti lity.
We report two Danish patients withSTK11 mosaicism detected in blood when using Next-Generation Sequencing. This is only the sixth and seventh patient reported in the literature, and we compare phenotypes of the reported cases. The results indicate thatSTK11 mosaicism is more frequent than anticipated and highlight that mosaicism should be considered in patients with clinical suspicion of PJS or patients fulfilling the diagnostic criteria.
Condition: Infertility, Female Intervention: Behavioral: Mindfulness based psychological intervention Sponsor: University Hospital, Geneva Not yet recruiting
Conditions: Adenoma Colon; Serrated Polyp; Serrated Adenoma; Colorectal Neoplasms Interventions: Procedure: Standard Endoscopic Mucosal Resection; Procedure: Cold Snare Endoscopic Mucosal Resection Sponsors: Oscar Nogales; SPANISH SOCIETY OF DIGESTIVE ENDOSCOPY Not yet recruiting
Authors: Bhalani V, Chang A, Adkins C, Chen SH, Scheiber M Abstract OBJECTIVE: To assess fertility outcomes in infertile women after hysteroscopic morcellation of intrauterine lesions. STUDY DESIGN: Retrospective case series from 2 U.S. fertility clinics. Women with intrauterine pathology and infertility (≥6 months' duration if age ≥35, or ≥12 months' duration if age
CONCLUSIONS: Two dimensional saline contrast sonohysterography proved to be a highly sensitive method for detection of endometrial polyps and submucous uterine leiomyoma making it a potential first line diagnostic method in the work-up for women with abnormal uterine bleeding. More studies are necessary for conclusion on 3D saline contrast sonohysterography during the reproductive period. PMID: 27862503 [PubMed - as supplied by publisher]
ConclusionsTwo dimensional saline contrast sonohysterography proved to be a highly sensitive method for detection of endometrial polyps and submucous uterine leiomyoma making it a potential first line diagnostic method in the work‐up for women with abnormal uterine bleeding. More studies are necessary for conclusion on 3D saline contrast sonohysterography during the reproductive period.
Our objective was to define and propose a standardized magnetic resonance (MR) imaging structured report in patients with infertility to have clinical completeness on possible diagnosis and severity. Patients should be studied preferable on 3T equipment with a surface coil. Standard MR protocol should include high-resolution fast spin-echo T2-weighted, diffusion-weighted images and gradient-echo T1-weighted fat suppression images. The report should include ovaries (polycystic, endometrioma, tumor), oviduct (hydrosalpinx, hematosalpinx, pyosalpinx, peritubal anomalies), uterus (agenesia, hypoplasia, unicornuate, uterus dide...
Saline infusion sonohysterography is a minimally invasive adjunctive method to delineate endometrial abnormalities that usually have been detected during transvaginal and/or transabdominal pelvic ultrasound. This procedure also is requested during the work-up for infertility. Of particular importance is the evaluation of patients with abnormal uterine bleeding. The majority of the patients with abnormal uterine bleeding will have benign etiologies including endometrial atrophy, uterine submucosal leiomyomas, endometrial polyps, or endometrial hyperplasia. However, approximately 10% of postmenopausal patients with uterine b...
HOX genes convey positional identity that leads to the proper partitioning and adult identity of the female reproductive track. Abnormalities in reproductive tract development can be caused by HOX gene mutations or altered HOX gene expression. Diethylstilbestrol (DES) and other endocrine disruptors cause Müllerian defects by changing HOX gene expression. HOX genes are also essential regulators of adult endometrial development. Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 exp...