Polyisoprenylated cysteinyl amide inhibitors deplete K-Ras and induce caspase-dependent apoptosis in lung cancer cells.

CONCLUSION: Taken together, PCAIs may be potentially useful as targeted therapies that suppress NSCLC progression through disruption of Ras-mediated growth signaling. PMID: 30914025 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30914025?dopt=Abstract

Source: Current Cancer Drug Targets - March 24, 2019 Category: Cancer & Oncology Authors: Nkembo AT, Amissah F, Ntantie E, Poku RA, Salako OO, Ikpatt OF, Lamango NS Tags: Curr Cancer Drug Targets Source Type: research