Replacing function of impaired cystic fibrosis protein

A widely-used antifungal drug replaced the function of the mutated protein that causes cystic fibrosis in human lung cells grown in the lab, suggesting a potential therapy.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news

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Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Pharmacy, Pulmonology, FDA Approvals, Source Type: news
MONDAY, June 24, 2019 -- The indication for a cystic fibrosis treatment, Symdeko (tezacaftor/ivacaftor) tablets, has been expanded to treat children ages 6 years and older with cystic fibrosis and certain genetic mutations, the U.S. Food and Drug...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Corinne McKay says she'd always wanted to see Machu Picchu, and while the 57-year-old has cystic fibrosis, she said she figured she was healthy enough to do the trek now. So she did.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Saskatchewan Source Type: news
Conclusion: An electronic alert incorporated into the ED workflow to populate a discharge order set is effective to initiate asthma controller medication for poorly controlled pediatric patients. Additional data describing reasons for not prescribing ICS can further refine recommendations for ICS prescriptions, and provide a comprehensive strategy to support clinical decision for pediatric asthma control in acute care settings. PMID: 31226000 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
FDA expanded the indication for Symdeko for treatment of pediatric patients ages 6 years and older with cystic fibrosis who have certain genetic mutations.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Discussion –-       Bronchial atresia usually is benign and asymptomatic and is incidental finding&clinical manifestations may range from recurrent pulmonary infections to mild wheezing and dyspnea. Bronchial atresia is a congenital abnormality resulting from focal interruption of a lobar, segmental, or subsegmental bronchus with associated peripheral mucus impaction (bronchocele, mucocele) and associated hyperinflation of the obstructed lung segment. The apicoposterior segmental bronchus of the left upper lobe is most common site to be involved, followed by segmental bronc...
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs
The FDA has approved tezacaftor/ivacaftor tablets for use in children as young as 6 years with cystic fibrosis with certain genetic mutations in the CFTR gene.FDA Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pulmonary Medicine News Alert Source Type: news
FRIDAY, June 21, 2019 -- The indication for a cystic fibrosis treatment, Symdeko (tezacaftor/ivacaftor) tablets, has been expanded to treat children ages 6 years and older with cystic fibrosis and certain genetic mutations, the U.S. Food and Drug...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: 5 November 2019Source: Journal of Molecular Structure, Volume 1195Author(s): Tooba Siddiqui, Mohammad Khalid Zia, Syed Saqib Ali, Haseeb Ahsan, Fahim Halim KhanAbstractHydrogen peroxide (H2O2) is an important signalling molecule and a non-radical reactive oxygen species (ROS) which can convert into more potent oxygen radicals leading to oxidative stress. The correlation between oxidative stress and the cellular proteinase-antiproteinase balance has been a major component in the development of several pathologies such as emphysema and cystic fibrosis. The present studies attempt to explore the functional i...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Source Type: research
More News: Cystic Fibrosis | Health | National Institutes of Health (NIH)