Optimization of a sustainable biocatalytic process for the synthesis of ethylhexyl fatty acids esters

Publication date: Available online 23 March 2019Source: Catalysis TodayAuthor(s): Murcia, M. Serrano-Arnaldos, S. Ortega-Requena, F. Máximo, J. Bastida, M.C. MontielAbstractBiocatalytic synthesis of ethylhexyl palmitate and ethylhexyl stearate as natural alternatives of cyclomethicone has been studied. In this work the esters have been obtained with two commercial enzymes: Novozym®435 and Novozym®40086 in a “solvent free” system. Operational conditions have been optimized using experimental design and response surface methodology. In the optimum reaction conditions conversion values were higher than 85% in one hour in all the cases. Operation in vacuum reactors with constant N2 bubbling improved the obtained results since it favours water removal in the reaction shifting reaction equilibrium in the way of the synthesis. Besides, Candida antarctica lipase Novozym®435 was the most effective, reaching a conversion value of 98% in 45 minutes. However, cost study revealed that the process is cheaper when using Novozym®40086 in open-air reactors.Graphical abstract

Source: Catalysis Today - March 24, 2019 Category: Chemistry Source Type: research