Dual-modified Bufalin loaded liposomes for enhanced tumor targeting

Publication date: Available online 21 March 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Yongchao Zhang, Zhenfen Tian, Xiaotong Zhao, Na Li, Vasil M. Garamus, Peihao Yin, Aihua ZouAbstractBufalin, a traditional oriental medicine, has been incorporated into liposomes for better targeted drug delivery. Bufalin-loaded liposome (L-BF), bufalin-loaded PEGylated liposome (L-PEG-BF) and bufalin-loaded RGD targeted PEGylated liposome (L-RGD-PEG-BF) were successfully developed with homogeneous particle size and sufficient physical stability in 30 days. The entrapment efficiency (EE) and drug loading efficiency (DL) of bufalin in these liposomes were about 85.4-90.6 % and 6.0-6.6 %, respectively. The morphologies of these liposomes were determined as uniquely recognizable phospholipid bilayers of the vesicle membrane by the measurements of transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). L-BF, L-PEG-BF and L-RGD-PEG-BF exhibited improved anticancer efficacy compared to free bufalin. Moreover, L-RGD-PEG-BF showed higher inhibition on the proliferation of A549 cells than the other two non-targeted bufalin liposomes in cytotoxicity study, and the growth inhibition concentration (IC50) of L-RGD-PEG-BF (8.62 ± 0.74 ng/mL) was much lower than pure bufalin (20.37 ± 2.31 ng/mL). Both confocal and apoptosis assay indicated that L-RGD-PEG-BF was easier to be taken into...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research

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Publication date: Available online 19 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Kyi Mar Wai, Masahiro Umezaki, Ohn Mar, Mitsutoshi Umemura, Chiho WatanabeAbstractArsenic is a well-known toxic heavy metal that is naturally dispersed in groundwater. Whereas arsenic is widely accepted to be involved in oxidative stress damage, little is known about arsenic-induced oxidative damage in relationship to contaminated drinking water as a source. The aim of this study was to determine the association between arsenic exposure through drinking water and oxidative stress status by measuring levels of...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Publication date: Available online 18 April 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Jingwen Shi, Shuiping Liu, Yuan Yu, Changyu He, Lianjiang Tan, Yu-Mei ShenAbstractDevelopment of polymer-drug conjugate capable of controlled drug release is urgently needed for gastric cancer therapy. Herein, arginine-glycine-aspartic acid (RGD)-decorated polyethylene glycol (PEG)-paclitaxel (PTX) conjugates containing disulfide linkage were synthesized. The amphiphilic PEG-PTX conjugates were found to assemble into micelles (RGD@Micelles), which would be decomposed under the reduction of glutathione (GSH) and finally ...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
In this study, polyethylene glycol (PEG) and lactobionic acid (LA) modified chitosan (PLC) was synthesized and was used to coat poly(lactide-co-glycolide) (PLGA) nanoparticles for encapsulation and targeted release of As2O3 in liver cancer treatment. The As2O3-loaded PLGA/PLC nanoparticles (As2O3-PLGA/PLC NPs) were fabricated through double emulsion-solvent evaporation method and were optimized by orthogonal tests. As2O3-PLGA/PLC NPs presented suitable physical stability, positive charge, high encapsulation efficiency and drug loading, and good biocompatibility. As expected, the NPs can quickly release enough dose of As2O3...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
This study reports the synthesis and production of a relatively robust dual drug-loaded liposomal formulation by modified thin film hydration method which substantially entraps both the drugs. Even though there have been reports of the combinatorial regimen involving apigenin and 5-Flurouracil our study reports the optimal molar ratio for effective synergistic therapeutic application of this drug combination to alleviate colorectal cancer. The cytotoxicity and cellular effects of individual, combinatorial free drugs and their liposomal counterparts tested against two human colon cancer cell lines revealed significantly hig...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 19 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Elena V. SuprunAbstractPost-translational modifications (PTMs) occur during or after protein biosynthesis under the action of various specific enzymes or reactive oxygen and nitrogen species. These modifications affect a wide range of protein characteristics such as the size and charge of proteins, their activation state, enzyme activity, cellular localization, interacting partners, and life cycle. Imbalance in protein PTMs can lead to a development of various diseases, among them are cancer and diabetes. It is also genera...
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 19 April 2019Source: Nitric OxideAuthor(s): Hugo P. Monteiro, Elaine G. Rodrigues, Adriana K.C. Amorim Reis, Luiz S. Longo, Fernando T. Ogata, Ana I.S. Moretti, Paulo E. da Costa, Ana C.S. Teodoro, Maytê S. Toledo, Arnold SternAbstractCancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammator...
Source: Nitric Oxide - Category: Chemistry Source Type: research
In conclusion, this nanocomposite showed synergistic advantages in gene delivery and non-invasive MR imaging.Graphical abstract
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
In this study we evaluated the cytotoxicity of Pt(IV) complexes based on the oxaliplatin scaffold and the pro-oxidant indole-3-propionate in cisplatin-sensitive and cisplatin-resistant ovarian cancer cells. A series of five complexes was synthesized and characterized by 1H and 195Pt NMR spectroscopy, IR spectroscopy, mass spectrometry and elemental analysis; trans-[Pt(DACH)(ox)(IPA)(OH)] (1), trans-[Pt(DACH)(ox)(IPA)2] (2), trans-[Pt(DACH)(ox)(IPA)(bz)] (3), trans-[Pt(DACH)(ox)(IPA)(suc)] (4), and trans-[Pt(DACH)(ox)(IPA)(ac)] (5) (DACH = 1,2-diaminocyclohexane (1R,2R)-(−), ox = oxalate, IPA = indole-3-propionate, bz...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 19 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Anees A Ansari, Maqsood A Siddiqui, Aslam Khan, N. Ahmad, M. Alam, Ahmed Mohamed El-Toni, Abdulaziz A. Al-KhedairyAbstractSpherical shaped SiO2@Tb(OH)3 nanospheres (core-shell NSs) with an average grain size of 300-350 nm were successfully synthesized at a large scale via sol-gel process with subsequent heat treatment. XRD results demonstrated the non-crystalline nature of the sample even after coating with terbium hydroxide. TEM and SEM images clearly showed that the prepared sample was...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 19 April 2019Source: Toxicology ReportsAuthor(s): Dominic Augustine, Roopa S Rao, Jayaraman Anbu, K.N. Chidambara MurthyAbstractThe current protocol of cancer management includes surgery, radiotherapy and chemotherapy. However, these modalities have significant adverse effects and affect the quality of life. Further intensification of treatment is hindered as maximal toxicity levels are reached impeding improvement. Hence researchers are in the quest for adjunctive naturally available therapies that can alter tumor proliferation without causing significant adverse reactions. The present s...
Source: Toxicology Reports - Category: Toxicology Source Type: research
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