Vancomycin Therapeutic Regime Adjustment In Newborn And Infant With Bacterial Infection: Case Series.

CONCLUSION: The pharmacokinetic adjustment has been proven to be an useful and necessary tool to increase therapeutic efficacy and treatment benefits. Then the standard dose of vancomycin can be used to initiate therapy in neonates and infants admitted to the ICU, but after reaching the drug steady state, the dosing regimen should be individualized and guided by pharmacokinetic parameters. PMID: 30892160 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research

Related Links:

CONCLUSIONS Our findings reinforce the idea that MSSA and MRSA strains should be carefully monitored, owing to their high pathogenic potential.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Conclusion: Arbekacin can be considered as safe and effective alternative to vancomycin in the management of MRSA infections. PMID: 31313549 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Healthcare-associated infections (HAIs) continue to be an ongoing threat to patients. “Despite the best care, patients get infections,” Brian Gross, business lead, genomics for infectious disease at Philips, told MD+DI. Because they are “technically avoidable, there’s pressure on hospitals to drive their numbers down.” Healthcare system professionals have struggled with two main problems when trying to identify and act on infection risks, Gross explained. “The problem is two-fold. First, because of current tools, all...
Source: MDDI - Category: Medical Devices Authors: Tags: Software Source Type: news
Publication date: Available online 16 July 2019Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Hanna R.C. Shoen, Sasha J. Rose, Stephen A. Ramsey, Helio de Morais, Luiz E. BermudezAbstractRecords of all Diagnostic laboratory submissions from 2012 –2015 were examined and subjected to analysis according to species, location of infection, species of bacteria, and antibiotic resistance/susceptibility. A total of 23.8% of all culture isolates were Staphylococcus sp. Of those Staphylococcus, 43% were isolated from surgical site infections.Staphylococcus pseudintermedius accounted for approxim...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 July 2019Source: American Journal of Infection ControlAuthor(s): Shanice Cheatham, Dipendra Thapaliya, Mohammed Taha, Katherine Milliken, Mark R. Dalman, Jhalka Kadariya, Dylan Grenier, Tara C. SmithBackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is common in medical institutions. We sought to examine the prevalence of S aureus on environmental surfaces in nursing homes and to obtain molecular information on contaminating strains.MethodsA total of 259 environmental samples were collected from 7 different nursing homes in Northeast Ohio (NEO), from suburban, urban, and rura...
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
ConclusionData collected from a non-outbreak setting suggest the presence of different clones of MRSA from nasal swabs of HCWs belonging to the Department of Pediatrics and Surgery. The data collected by this study can be used as reference for other succeeding studies on the surveillance of MRSA among HCWs.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00159
Source: ACS Medicinal Chemistry Letters - Category: Chemistry Authors: Source Type: research
Antimicrobial drug discovery against drug-resistant bacteria is an urgent need. Beyond agents with direct antibacterial activity, anti-virulent molecules may also be viable compounds to defend against bacterial pathogenesis. Using a high throughput screen (HTS) that utilized, Caenorhabditis elegans infected with methicillin-resistant Staphylococcus aureus (MRSA) strain of MW2, we identified 4-(1,3-dimethyl-2,3-dihydro-1H-benzimidazol-2-yl)phenol (BIP). Interestingly, BIP had no in vitro inhibition activity against MW2, at least up to 64 µg/mL. The lack of direct antimicrobial activity suggests that BIP could inhibit ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, we have designed a set of new LL-37 peptides with varying antimicrobial activities, opening the door to potential topical treatment of infections involving different drug-resistant pathogens.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Conclusions: The majority of S. aureus IAIs were methicillin-susceptible S. aureus. All children with immediate implant removal and most children with retained implants were treated successfully with surgery and antibiotic therapy.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
More News: Biotechnology | Intensive Care | MRSA | Perinatology & Neonatology | Study