Effects of Liraglutide Plus Phentermine in Adults with Obesity Following 1 Year of Treatment by Liraglutide Alone: A Randomized Placebo-Controlled Pilot Trial

This pilot study evaluated whether adding phentermine to liraglutide would induce further weight loss in participants who had previously lost weight with liraglutide alone.Subjects/MethodsParticipants were 45 adults with obesity (75.6% female, 55.6% white, body mass index = 34.3 ±4.7 kg/m2) who had lost an average of 12.6±6.8% of initial weight during a prior 1-year randomized trial with liraglutide and intensive behavioral treatment. Participants were re-randomized, in a double-blinded fashion, to liraglutide 3.0mg plus phentermine 15.0mg (liraglutide-phentermine) or lir aglutide plus placebo (liraglutide-placebo).

Source: Metabolism - Clinical and Experimental - March 18, 2019 Category: Biomedical Science Authors: Jena Shaw Tronieri, Thomas A. Wadden, Olivia A. Wals, Robert I. Berkowitz, Naji Alamuddin, Kathryn Gruber, Sharon Leonard, Ariana M. Chao Source Type: research