Post-transplant donor specific antibody is associated with poor kidney transplant outcomes only when combined with both T-cell –mediated rejection and non-adherence

Post-transplant donor specific antibody (DSA) is associated with poor renal allograft outcomes. However, variable timing of DSA assessment and inclusion of patients who undergo desensitization treatments have hindered our understanding of its consequences and limited its predictive value. Here we prospectively studied non-desensitized patients to determine factors associated with poor four-year outcomes in patients who developed post-transplant DSA. Using serial monitoring, 67 of 294 patients were found to develop DSA by one year.

Source: Kidney International - March 18, 2019 Category: Urology & Nephrology Authors: Aravind Cherukuri, Rajil Mehta, Akhil Sharma, Puneet Sood, Adriana Zeevi, Amit D. Tevar, David Rothstein, Sundaram Hariharan Tags: Clinical Investigation Source Type: research