Comparative Evaluation of Median Versus Youden Index Dichotomization Methods: Exposure –Response Analysis of Mycophenolic Acid and Acyl-Glucuronide Metabolite

ConclusionThe results demonstrated in this analysis suggest that both the Youden index and the median methods provide similar conclusions when dichotomization of a continuous variable is considered. However, confirmation of these conclusions comes from future powered studies that include a larger number of subjects.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research