Development of a dosing device for individualized dosing of orodispersible warfarin films
This study covers the development of a dosing device that enables flexible dosing of films within the pharmacopoeial requirements. The prototype was produced with the 3D-printing technique fused filament fabrication. The developed and produced prototype of the device was tested for the uniformity of doses according to Ph.Eur. 2.9.27 and 2.9.40. A ribbon as model film and an oral film with HPMC as polymer matrix met the specifications for both tests for three different lengths dispensed with the prototype of the dosing device (HPMC film: AV = 11.30 (1cm), 12.04 (2cm) and 10.19 (3cm)). A second oral film with a polymer matrix from PVA and HPMC exceeded the threshold for the shortest piece of 1 cm (AV = 26.54) because of slight splintering during the cutting process, likely due to too little plasticizer in the formulation. A successful device development and a use within the specifications of the European Pharmacopoeia is demonstrated.Graphical abstract
Date: Monday, 11 18, 2019; Speaker: Barton Haynes, M.D., Frederic M. Hanes Professor of Medicine and Immunology, Duke University School of Medicine; Carolyn Coyne, Ph.D., Professor of Pediatrics, University of Pittsburgh; Matthias Gromeier, M.D., Professor of Neurosurgery, Duke University School of Medicine; Adam Zlotnick, Ph.D., Professor of Molecular and Cellular Biochemistry, Indiana University; Malcolm Martin, M.D., Chief, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases; Lipsett Auditorium of the Clinical Center
Date: Tuesday, 07 16, 2019; Speaker: Carolyn Sufrin, M.D., Ph.D., Assistant Professor, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine; https://orwh.od.nih.gov/about/newsroom/events/; Videocast Event
Date: Wednesday, 07 17, 2019; Speaker: Mary Kearney, PhD, Head, Translational Research Unite, HIV Dynamics and Replication Program, Center, National Cancer Institute; https://bit.ly/2RyT8Kw
Publication date: Available online 22 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Luisa Taylor, Morgan Waller, Jay PortnoyAbstractTelemedicine (TM) involves the use of technology to provide medical services to patients who live at a distance. It can be used asynchronously for interpretation of tests (spirometry, skin tests imaging studies), and for communication of information when the simultaneous presence of provider and patient is unnecessary. Synchronous encounters can be either unscheduled and initiated on-demand by patients or they can be facilitated substitutes for in-perso...
Publication date: Available online 22 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Stephen Betschel, Ernie Avilla, Amin Kanani, Monika Kastner, Paul Keith, Karen Binkley, Gina Lacuesta, Rozita Borici-Mazi, Jacquie Badiou, Anne Rowe, William H. Yang, Susan WasermanAbstractBackgroundHAE patients present to the emergency department (ED), where their symptoms are often incorrectly attributed to common allergic and gastrointestinal conditions resulting in major delays in diagnosis and treatment.ObjectiveThe goal of this study was to develop a rapid triage HAE tool for ED settings.Method...
ConclusionOur data support the concept of MDH as a distinct and rare subgroup of DH. The prevalence in our database was 2.5% in the total DH alleged patient population and 0.5% of the demonstrated DH. Skin testing and DPT are mandatory for confirming the diagnosis.
ConclusionLong-term Abatacept therapy is effective in the majority of patients with LRBA deficiency.
ConclusionThus our results showed that higher IL-37 was associated with increased insulin sensitive in elderly type 2 DM patients through suppressing the gut microbiota dysbiosis.
Planning grants to support communities seeking innovative ways to address the particular mobility challenges experienced by low-income community members for whom a lack of transportation is an obstacle to the pursuit of economic, health, and social well being. Geographic coverage: Nationwide -- Community Transportation Association of America, Federal Transit Administration, National Center for Mobility Management
Operating before birth can minimize nerve damage caused by severe defects in tissue around the spinal column.