Novel Triple-dose Tuberculosis Retreatment Regimens: How to Overcome Resistance Without Creating More

Condition:   Tuberculosis, Pulmonary Interventions:   Drug: 6EH³RZ;   Drug: 6EHR³Z;   Drug: 6EHRZLfx Sponsors:   Institute of Tropical Medicine, Belgium;   Damien Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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This airborne infectious disease is believed to be more than 3 million years old. Here's what you need to know.
Source: Nursing Made Incredibly Easy - Category: Nursing Tags: Feature Source Type: research
Publication date: Available online 9 December 2019Source: Microbiological ResearchAuthor(s): Vivek Vinod, Sukhithasri Vijayrajratnam, Anil Kumar Vasudevan, Raja BiswasAbstractBacterial cell surface adhesins play a major role in facilitating host colonization and subsequent establishment of infection. The surface of Mycobacterium tuberculosis, owing to the complex architecture of its cell envelope, expresses numerous adhesins with varied chemical nature, including proteins, lipids, lipoproteins, glycoproteins and glycopolymers. Studies on mycobacterial adhesins show that they bind with multifarious host receptors and extrac...
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Abstract This paper presents the first comprehensive report on traditional uses of medicinal shrubs of Rawalakot city, district Poonch, Azad Jammu and Kashmir, Pakistan. Ethobotanical data obtained from 120 informants were analyzed by relative frequency citation, use value, family use value, informant consensus factor, fidelity level and Jaccard index. In total, 41 shrubs belonging to 24 families and 34 genera were documented. Rosaceae was reported the most dominant family in the area (six species) and Berberidaceae showed maximum family use value (0.68). Leaves (35%) and fruits (33%) were the most commonly used plant part...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Mycobacterium tuberculosis (Mtb) resides in a quarter of the world's population and is the causative agent for tuberculosis (TB), the most common infectious reason of death in humans today. Although cellular immunity has been firmly established in the control of Mtb, there is growing evidence that antibodies may also modulate the infection. More specifically, certain antibody features are associated with inflammation and are divergent in different states of human infection and disease. Importantly, TB impacts not just the healthy but also those with chronic conditions. While HIV represents the quintessential comorbid condi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study introduces PANPASCO, a computational pan-genome mapping based, pairwise distance method that is highly sensitive to differ ences between cases, even when located in regions of lineage specific reference genomes. We show that our approach is superior to previously published methods in several datasets and across differentMycobacterium tuberculosis lineages, as its characteristics allow the comparison of a high number of diverse samples in one analysis —a scenario that becomes more and more likely with the increased usage of whole-genome sequencing in transmission surveillance.
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
AbstractThe aim of this work is to reveal impacts of a nuclear power plant on environmental radioactivity and public health since commission in the South China Sea. After long-term monitoring, it turns out that radioactivity in ambient air environment, water, soil, sweet potato, rice, chicken, lamb, butterfish and prawn meet demands of national environment protection standards and food safety standards in China. After 6 years ’ statistic check of local residents, the top tree diseases before and after the plant’s commission remained pulmonary tuberculosis, hand-foot-and-mouth disease, and hepatitis B. Incidence...
Source: Journal of Radioanalytical and Nuclear Chemistry - Category: Nuclear Medicine Source Type: research
AbstractThis paper presents a probable case of subligamentous tuberculous spondylitis (STBS), a rare form of extra ‐pulmonary tuberculosis, diagnosed in the skeleton of a middle‐aged male discovered in the ossuary of the Franciscan crypt of the St. Anthony and St. Eusebius church, which lies in north‐western Italy. The skeleton can be dated back between the 17th‐19th centuries. This rare type of tubercul osis was identified in the thoracic and lumbar spine, with no further evidences at the level of the cranial and other postcranial bones. The concomitance of osteoclastic and osteoblastic activities, scalloping, rea...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
ConclusionThis study demonstrates that ESAT6 bound with TLR2 can activate iNOS/NO and ROS signalings to reduce the trimethylation of H3K27 resulting in the increment of EMMMs expression that is beneficial to the transition of macrophages into epithelioid macrophages. However, hypoxia can inhibit this transition event. This study has provided new evidence of pathogenesis of granuloma caused by Mtb and also proposed new ideas for the treatment of TB.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Bilateral lung parenchymal involvement is seen in infective as well as noninfective conditions, appearing as focal or diffuse lung disease. PET/CT with FDG helps in characterization (increased glucose utilization is seen by both inflammatory and neoplastic cells). In this article, we describe the spectrum of patterns of FDG uptake and associated CT changes involving bilateral lung parenchyma. Benign conditions described are aspiration pneumonia; pulmonary toxicity by bleomycin; infections, namely, sarcoidosis, miliary pulmonary tuberculosis, and pulmonary nocardiosis; and inflammatory conditions such as pulmonary Langerhan...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
CONCLUSION: During the last century, AADRs among males declined more slowly than among females. Although the gap diminished in recent decades, exploration of social and behavioral factors may inform interventions that could further reduce death rates among males. PMID: 31804898 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
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