Screening spreading depolarizations during epilepsy surgery

ConclusionsSDs were not detected during intraoperative recordings of epilepsy surgery using AC- or DC-amplifiers.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research

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Publication date: Available online 19 March 2019Source: SeizureAuthor(s): Ilaria Lagorio, Federico Zara, Salvatore Striano, Pasquale StrianoAbstractFamilial adult myoclonic epilepsy (FAME), also described with different acronyms (ADCME, BAFME, FEME, FCTE and others), is a high-penetrant autosomal dominant condition featuring cortical hand tremors, myoclonic jerks, and occasional/rare convulsive seizures. Prevalence is unknown since this condition is often under-recognized, but it is estimated to be less than 1/35,000. The disease usually starts in the second decade of life and has been genetically associated with at least ...
Source: Seizure - Category: Neurology Source Type: research
ConclusionThis study further expands the genotypic and phenotypic spectrum of epilepsies associated with GABRG2 variants. More knowledge is still needed about the influence of the environment, genetic background and other epilepsy susceptibility genes on the phenotype of the specific GABRG2 variants.
Source: Seizure - Category: Neurology Source Type: research
ConclusionThe LAEP may inform a high risk of suicidality in PWDRE. Referring to this, clinicians can discern suicidal problems in their epilepsy clinics.
Source: Seizure - Category: Neurology Source Type: research
ConclusionsThe rate of suicidal ideation and behavior in this sample of EMU patients was higher compared with other inpatient populations. The presence of a psychiatric disorder was independently associated with a higher risk. There was no statistically significant difference in the risk between those with ES and PNES. Screening for suicide risk, suicidal ideation, and behavior is recommended for all patients admitted to the EMU.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: May 2019Source: Epilepsy &Behavior, Volume 94Author(s): Ann Hempel, Michael Frost, Nitin AgarwalAbstractFew studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. For all patients...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionThis study collected a large group of dog owners with seizures reporting behavioral changes in their dogs before their seizures occurred. This was associated with the presence of preictal symptoms. The seizure-alerting behavior of the dog may have a positive influence on the bond between the owner and the dog.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: 23 May 2019Source: Journal of Ethnopharmacology, Volume 236Author(s): Cheryl LansAbstractEthnopharmacological relevanceThere are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset t...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Condition:   Epilepsies, Partial Intervention:   Diagnostic Test: electrical source imaging Sponsor:   Cliniques universitaires Saint-Luc- Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Epilepsy Interventions:   Device: EpiTel Epilog;   Device: Empatica E4;   Device: GENEActiv Sponsor:   Seer Medical Pty Ltd Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aimed to study the possible alterations in neural differentiation process of human induced pluripotent stem cells (hiPSCs) related to migration and synaptic aspects from fibroblasts of two individuals affected by FCD type IIb (45-year-old male and 12-year-old female) and normal individuals. At the days 14th, 22nd and 35th, hiPSCs were neural differentiated and analyzed. Using qRT-PCR approach, the expression of 9 genes associated with synaptic and neural migration were quantified. Diagnostic of both patients was consistent with FCD type IIb. Our results showed that in all processes and groups, individuals with d...
Source: Neuroscience - Category: Neuroscience Source Type: research
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