Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient

Publication date: Available online 7 March 2019Source: Stem Cell ResearchAuthor(s): Jun Ma, Ruiyun Guo, Yongzhou Song, Jing Zhang, Baofeng Feng, Asiamah Ernest Amponsah, Desheng Kong, Jingjing He, Wei Zhang, Aijing Liu, Lin Wei, Sanbing Shen, Timothy O'Brien, Huixian CuiAbstractWe generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.
Source: Stem Cell Research - Category: Stem Cells Source Type: research