Paracellular calcium transport in the proximal tubule and the formation of kidney stones.

Paracellular calcium transport in the proximal tubule and the formation of kidney stones.
Am J Physiol Renal Physiol. 2019 Mar 06;:
Authors: Curry JN, Yu ASL
Abstract
The proximal tubule (PT) is responsible for the majority of calcium reabsorption by the kidney. Most PT calcium transport appears to be passive, although the molecular facilitators have not been well-established. Emerging evidence supports a major role for PT calcium transport in idiopathic hypercalciuria and the development of kidney stones. This review will cover recent developments in our understanding of PT calcium transport and the role of the PT in kidney stone formation.
PMID: 30838875 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - March 5, 2019 Category: Physiology Authors: Curry JN, Yu ASL Tags: Am J Physiol Renal Physiol Source Type: research