Abnormalities in chemokine receptor recycling in chronic lymphocytic leukemia.

Abnormalities in chemokine receptor recycling in chronic lymphocytic leukemia.
Cell Mol Life Sci. 2019 Mar 04;:
Authors: Patrussi L, Capitani N, Baldari CT
Abstract
In addition to their modulation through de novo expression and degradation, surface levels of chemokine receptors are tuned by their ligand-dependent recycling to the plasma membrane, which ensures that engaged receptors become rapidly available for further rounds of signaling. Dysregulation of this process contributes to the pathogenesis of chronic lymphocytic leukemia (CLL) by enhancing surface expression of chemokine receptors, thereby favoring leukemic cell accumulation in the protective niche of lymphoid organs. In this review, we summarize our current understanding of the process of chemokine receptor recycling, focusing on the impact of its dysregulation in CLL.
PMID: 30830241 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - March 3, 2019 Category: Cytology Authors: Patrussi L, Capitani N, Baldari CT Tags: Cell Mol Life Sci Source Type: research