The motor protein Myo1c regulates transforming growth factor- β-signaling and fibrosis in podocytes

Transforming growth factor- β (TGF-β) is known to play a critical role in the pathogenesis of many progressive podocyte diseases. However, the molecular mechanisms regulating TGF-β signaling in podocytes remain unclear. Using a podocyte-specific Myo1c knockout, we demonstrate whether Myo1c is critical for TGF-β-signaling i n podocyte disease pathogenesis. Specifically, podocyte-specific Myo1c knockout mice were resistant to fibrotic injury induced by Adriamycin or nephrotoxic serum. Further, loss of Myo1c also protected from injury in the TGF-β-dependent unilateral ureteral obstruction mouse model of renal interstiti al fibrosis.

Source: Kidney International - March 3, 2019 Category: Urology & Nephrology Authors: Ehtesham Arif, Ashish K. Solanki, Pankaj Srivastava, Bushra Rahman, Brian R. Tash, Lawrence B. Holzman, Michael G. Janech, Ren é Martin, Hans-Joachim Knölker, Wayne R. Fitzgibbon, Peifeng Deng, Milos N. Budisavljevic, Wing-Kin Syn, Cindy Wang, Joshua H. Tags: Basic Research Source Type: research