A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment

In this study, we proposed to integrate the CLI technique with the radionuclide treatment as a “see-and-treat” approach, and evaluated the performance of the pinhole collimator-based CLI technique. The detection of Cerenkov luminescence during radionuclide therapy was simulated using the Monte Carlo technique for breast cancer treatment as an example. Our results show that with the pinhol e collimator-based configuration, the location, size and shape of the tumors can be clearly visualized on the Cerenkov luminescence images of the breast phantom. In addition, the CLI of multiple tumors can reflect the relative density of radioactivity among tumors, indicating that the intensity of C erenkov luminescence is independent of the size and shape of a tumor. The current study has demonstrated the high-quality performance of the pinhole collimator-based CLI in breast tumor imaging for the “see-and-treat” multi-modality treatment.
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research