Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'.

Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'.
Phys Med Biol. 2019 Feb 27;64(5):058002
Authors: Cao W, Khabazian A, Yepes P, Lim G, Poenisch F, Grosshans D, Mohan R
Abstract
In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, it could be used to optimize LET efficiently while dose constraints are maintained.
PMID: 30811349 [PubMed - in process]

Source: Physics in Medicine and Biology - February 27, 2019 Category: Physics Authors: Cao W, Khabazian A, Yepes P, Lim G, Poenisch F, Grosshans D, Mohan R Tags: Phys Med Biol Source Type: research