Pharmacologic Intervention for the Treatment and Prevention of Delirium

The objective of the analyses was to ascertain if new agents or combinations of existing agents currently available can be substantiated as superior to placebo or widely used medications (eg, haloperidol) for the treatment and prevention of delirium. The authors perform an extensive review of the extant literature of well-designed and controlled clinical trials. Fifty-eight randomized clinical trials (RCTs) were included in the analyses, of which 20 RCTs with a total of 1435 participants compared the outcomes of treatment of delirium and 38 RCTs with a total of 8168 participants examined prevention.
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research