Kidney Disease Affects Revascularization Outcomes

WEDNESDAY, Feb. 27, 2019 -- The presence of comorbid chronic kidney disease (CKD) negatively impacts myocardial revascularization outcomes in patients with type 2 diabetes mellitus (T2DM), according to a study published in the Feb. 5 issue of the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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The prevalence of type 2 diabetes mellitus (T2DM) has increased dramatically in China and elsewhere [1], and T2DM is associated with a substantial increase in all-cause mortality [2]. Impaired glucose tolerance (IGT), also known as pre-diabetic state, has been shown to be a significant risk factor for T2DM. Moreover, IGT itself is significantly associated with microvascular and cardiovascular complications [3]. Studies have shown increased prevalence of retinopathy and chronic kidney disease among subjects with IGT [4,5], and reversal of IGT to normal glucose regulation has been shown to significantly reduce the risk of ca...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Abstract: Diabetes mellitus is the leading cause of chronic kidney disease (CKD) in the US. An increasing number of glucagon-like peptide-1 receptor agonists are available for diabetes management. Differences between medications in this class, as well as limited data on patients with CKD, underscore the importance of a patient-centered approach to care.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: TYPE 2 DIABETES MELLITUS: CE Connection Source Type: research
AbstractDiabetes mellitus affects over 20% of people aged  >  65 years. With the population of older people living with diabetes growing, the condition may be only one of a number of significant comorbidities that increases the complexity of their care, reduces functional status and inhibits their ability to self-care. Coexisting comorbidities may compete for the attention of the patient and their healthcare team, and therapies to manage comorbidities may adversely affect a person’s diabetes. The presence of renal or liver disease reduces the types of antihyperglycemic therapies available for us...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
SUMMARY The prevalence of type 2 diabetes mellitus (T2DM) in the elderly grew sharply over the last decade. Reduced insulin sensitivity and secretory capacity, weight gain, sarcopenia, and elevated adiposity are all common metabolic and body changes in the aging population that favor an increased risk of hypoglycemia, frailty syndrome, falls, and cognitive dysfunction. First line antidiabetic therapy is frequently not safe in older individuals because of its high risk of hypoglycemia and prevalent co-morbid diseases, such as chronic kidney disease, osteoporosis, cardiovascular disease, and obesity. Sodium-glucose cotranspo...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
In this study we evaluated endocan and endoglin levels in diabetes patients with and without albuminuria and compared them with healthy subjects. Therefore we aimed at gaining a better understanding of the role of angiogenesis in diabetic nephropathy and to assess the predictive role of endocan and endoglin as markers of diabetic nephropathy progression. Material and methods: Ninety-six type 2 diabetes patients were classified according to their 24-hour urinary albumin excretion rate. Forty type 2 diabetes patients with normoalbuminuria (urinary albumin excretion
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
A 66-year-old white man with a medical history of chronic kidney disease (CKD) stage 3a (baseline creatinine level of 1.4 mg/dL; normal 0.74-1.35 mg/dL) with an estimated glomerular filtration rate of 52 mL/min per 1.73 m2 per the Chronic Kidney Disease Epidemiology collaboration equation, controlled type 2 diabetes mellitus with microalbuminuria, hypertension, hyperlipidemia, and medically complicated obesity (body mass index, 37) presented to his primary care clinic with episodes of orthostatic light-headedness that had been occurring for approximately 2 weeks.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents' clinic Source Type: research
Abstract Patients with type 2 diabetes mellitus (T2DM) are exposed to non-alcoholic fatty liver disease (NAFLD), a comorbidity associated with cardiovascular disease and chronic kidney disease, and which may progress to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Sodium-glucose cotransporter type-2 (SGLT2) inhibitors are glucose-lowering agents that improve glucose control while promoting weight loss and lowering serum uric acid levels. These agents may exert cardiovascular and renal protection in T2DM patients with established cardiovascular disease. Recent findings from both randomized controll...
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
Obesity is the global epidemic of the 21st century: about 1.5 billion adults worldwide are overweight, and among them, about 200 million men and 300 million women are obese [1]. In some countries, the prevalence of obesity has exceeded 50%, as in Tonga (men), and in Kuwait, Kiribati, Micronesia, Libya, Qatar, Tonga and Samoa (women) [2]. The prevalence of overweight and obesity are also increasing in children and adolescents in developed (about 25%) and in developing countries (about 13%) [2]. Obesity has been associated with many comorbidities, including type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (N...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Abstract BACKGROUND: LEADER trial (Liraglutide Effect and Action in Diabetes: Evaluation of CV Outcome Results) results demonstrated cardiovascular benefits for patients with type 2 diabetes mellitus at high cardiovascular risk on standard of care randomized to liraglutide versus placebo. The effect of glucagon-like peptide-1 receptor agonist liraglutide on cardiovascular events and all-cause mortality in patients with type 2 diabetes mellitus and chronic kidney disease is unknown. Liraglutide's treatment effects in patients with and without kidney disease were analyzed post hoc. METHODS: Patients were random...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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