The effects of cinnamaldehyde on acute or chronic stress-induced anxiety-related behavior and locomotion in male mice.

The effects of cinnamaldehyde on acute or chronic stress-induced anxiety-related behavior and locomotion in male mice. Stress. 2019 Feb 26;:1-8 Authors: Etaee F, Komaki A, Faraji N, Rezvani-Kamran A, Komaki S, Hasanein P, Taheri M, Omidi G Abstract Anxiety and stress are considered as universal psychiatric exhibitions of the present societies and lifestyles. Several experiments have been conducted to examine natural anxiolytic agents to find out an alternative to synthetic anxiolytic drugs. The present study investigated the anxiolytic effects of cinnamaldehyde (Cin) on mice behavior in the elevated plus maze (EPM) and open field (OF) tests. Sixty male Swiss mice, weighing 20-30 g, were divided into six groups including: acute stress + mazola oil; chronic stress + oil; acute stress + Cin (20 mg/kg); chronic stress + Cin; non-stress + oil; and non-stress + Cin groups. The groups were administered for seven days (once a day). The acute stress + Cin group showed a meaningful rise in the percentage of entries into the open arms compared to the acute stress + oil group (p <.05). The percentage of time spent in the open arms in the chronic stress + Cin group was significantly higher compared to the chronic stress + oil group (p < .01). The percentage of entries into the open arms increased significantly (p < .01) in the chronic stress + Cin group in comparison with the chro...
Source: Stress - Category: Research Tags: Stress Source Type: research