Regulation of MFGE8 by the intergenic coronary artery disease locus on 15q26.1

A recently identified locus for coronary artery disease (CAD) tagged by rs8042271 is in a region of tight linkage disequilibrium (LD) between 2 genes (MFGE8, ABHD2) previously linked to atherosclerosis. Here we have explored the regulatory framework of this region to identify its functional relationship to CAD.

Source: Atherosclerosis - February 22, 2019 Category: Cardiology Authors: S ébastien Soubeyrand, Majid Nikpay, Adam Turner, Ann-Thu Dang, Mikayla Herfkens, Paulina Lau, Ruth McPherson Source Type: research