Common acid reflux medications linked to increased kidney disease risk

(University of California - San Diego) Mining a large database of adverse reactions to medications, UC San Diego researchers found that people who took proton pump inhibitors (e.g., Prilosec, Nexium) for heartburn and acid reflux were more likely to experience kidney disease than people who took other forms of antacid.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Purpose of review Gastroesophageal reflux disease (GERD) is primarily a motor disorder, but its pathogenesis is multifactorial. Although gastric acid secretion is usually normal in GERD patients, treatment with proton pump inhibitors (PPIs) has become the standard of care, despite increasing awareness of their shortcomings. In this article, a new class of antisecretory drugs (namely potassium-competitive acid blockers, P-CABs), developed to overcome these limitations, is discussed. Recent findings P-CABs block the K+ exchange channel of the proton pump, resulting in rapid, competitive, reversible inhibition of acid se...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: ESOPHAGUS: Edited by Stuart J. Spechler Source Type: research
(Wiley) Individuals who are obese often experience heartburn and other symptoms of acid reflux. Previous research indicates that gastric bypass surgery for obesity helps alleviate symptoms in the short term, but a new Alimentary Pharmacology&Therapeutics study finds that these benefits often are not long-lasting.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
New research finds a link between proton pump inhibitors and heightened risk of death from heart disease, kidney disease, and stomach cancer.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Acid Reflux / GERD Source Type: news
CONCLUSION: The QoLRAD test measuring quality of life, except some subdomains in our study that we performed on patients diagnosed with GERD, was found to be valid and reliable. PMID: 31144656 [PubMed - in process]
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Tags: Turk J Gastroenterol Source Type: research
CONCLUSION Male gender and hiatal hernia were associated with EE. Aged patients, smoking and hiatal herni a were related to severe EE. It is suggested that the risk factors for EE and non-EE types are different. Cohort studies are necessary to identify the exact mechanisms involved in each disease form.RESUMO CONTEXTO: A doen ça do refluxo gastroesofágico (DRGE) é uma das doenças digestivas mais comuns na prática médica e deve ser suspeitada de acordo com os seus sintomas clínicos, podendo ser classificada em esofagite erosiva (EE) de acordo com os achados de endoscopia. OBJ...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
Authors: Hajer J, Novák M, Rosina J Abstract Gastroesophageal reflux disease (GERD) is a rather common disease with a prevalence reaching up to 10 or 20% in the western world. The most specific symptoms which point to the diagnosis of GERD are feelings of heartburn and the regurgitation of acidic stomach contents into the esophagus. However, a certain number of patients do not respond to standard therapy, and in these cases, it is necessary to resort to other treatment methods, such as laparoscopic fundoplication or electrostimulation of the lower esophageal sphincter. The aim of our work was to design and m...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Conclusions Transoral incisionless fundoplication with EsophyX is an effective therapeutic option for symptomatic gastroesophageal reflux disease patients, with Hill grades I – II or hiatal hernia 
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
ConclusionWe observed a high prevalence of esophageal symptoms and of HRM abnormalities. However, there was no clear association between symptomatology and HRM findings. HRM does not seem to accurately predict upper GI symptomatology.ResumenAntecedentesLa afectación esofágica en la esclerosis sistémica causa impacto en la morbimortalidad. La manometría de alta resolución evalúa la afectación esofágica. Nuestro objetivo fue categorizar el trastorno motor esofágico en pacientes con esclerosis sistémica por HRM.MétodosSe realizó un estudio obs...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
(Natural News) The pharmaceutical drugs commonly prescribed to treat gastroesophageal reflux disease (GERD) have a number of serious side effects. Among other negative effects, proton-pump inhibiting (PPI) drugs can prevent the proper absorption of nutrients by the gastrointestinal system, which makes patients more likely to develop cardiovascular disease. Also known as “acid reflux” and “heartburn,”...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Both heartburn and heart attacks can cause pain in the center of the chest. Heartburn is a symptom of acid reflux and gastroesophageal reflux disease (GERD). As a heart attack is a medical emergency, being able to tell the difference between heartburn and cardiac chest pain is crucial. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Acid Reflux / GERD Source Type: news
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